Università degli Studi di Milano
Please find below the current offer of thesis projects for the Master Degree "Molecular Biotechnology and Bioinformatics".
You must contact by e-mail the professor offering the position to schedule a meeting. During the meeting you will get detailed information about the project. To finalize the reqiuest you must fill in Internship Request Form ITA ENG

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MASTER IN Molecular Biotechnology and Bioinformatics (MBB)

  Responsible professor Other professor Topic Description References Period Available positions Last modified
Cattaneo Elena Chiara Zuccato Cellule staminali e malattie neurodegenerative

Studio della funzione del gene Huntington mediante approccio Evo-Devo

http://users2.unimi.it/labcattaneo/wordpress-eng/

Gennaio 2019 1 08/03/2018
Cattaneo Elena Chiara Zuccato, Marta Valenza Cellule staminali e malattie neurodegenerative

Identificazione di meccanismi molecolari alla base della malattia di Huntington e validazione in modelli animali di malattia

http://users2.unimi.it/labcattaneo/wordpress-eng/

Gennaio 2019 2 08/03/2018
Cattaneo Elena Cellule staminali e malattie neurodegenerative

Studio delle cellule staminali embrionali umane e delle cellule staminali pluripotenti indotte da pazienti Huntington

http://users2.unimi.it/labcattaneo/wordpress-eng/

Gennaio 2019 1 08/03/2018
Horner David Stephen Sergio Marchini Genomics of Myxoid liposarcoma

Myxoid liposarcoma is a soft tissue sarcoma and represents one third of all types of liposarcomas. It is a very rare tumour having an incidence of 30  ...

from september 2018 1-2 08/05/2018
Gregis Veronica Martin Kater Plant Molecular Genetics & Biotechnology

Reproductive meristem development in Arabidopsis thaliana and rice.

The aim of the project is to characterize the function of new genes involved  ...

Harrop et al. (2016) Plant J. 86(1):75-88. Mantegazza et al. (2014). Plant J. 79, 861-877. Gregis et al. (2013). Genome Biol. 14, R56

da concordare col docente 0 10/05/2018
Gregis Veronica Martin Kater Plant Molecular Genetics

Studying the recruitment of master regulatory transcription factor complexes to the DNA.

Functional characterization of master regulatory transcrip ...

Gregis et al. (2013) Genome Biol. 14(6):R56. doi: 10.1186/gb-2013-14-6-r56. Simonini et al. (2012). Plant Cell 24, 4163-4172

da concordare col docente 0 10/05/2018
Ricagno Stefano Biochimica - Biologia Strutturale

Biophysical and structural characterization of proteins with a tendency to amyloid aggregation linked to human pathologies.

 

The research focuses o ...

Camilloni et al Sci Rep 2016, Saga et al Sci Rep 2016, Oberti et al Sci Rep 2017

settembre-ottobre 2018 0 14/05/2018
Marini Federica Achille Pellicioli Molecular basis of genome instability

FANCP, factor involved in the blood disorder and tumor predisposition syndrome Fanconi anemia and in cancer development: study of its role in the main ...

Marini F., Pellicioli A. (2014) Regulation of DSB Repair by Cell Cycle Signaling and the DNA Damage Response. Molecular Life Sciences. DOI10.1007/978- ...

From September/October 2018 0 14/05/2018
Morelli Carlo Biocatalysis

Enzymatic synthesis of naturally occurring flavor enhancers.

negotiable, starting from June 2018 1 23/02/2018
Morelli Carlo Bioorganic chemistry

Studies on the mechanism and on substrate specificity of bacterial gamma-glutamyl transferases.

negotiable, starting from June 2018 1 23/02/2018
Morelli Carlo Bioorganic chemistry

Bacterial enzymes involved in degradation of natural polymers.

negotiable, starting from June 2018 1 23/02/2018
Nardini Marco Giovanna Musco (musco.giovanna@hsr.it) Ospedale San Raffaele Structural Biology

Structural studies (nuclear magnetic resonance) of the PHD finger domain of the lysine-specific methyltransferase 2D KMT2D

Kabuki Syndrome (KS, OMI ...

http://research.hsr.it/en/divisions/genetics-and-cell-biology/biomolecular-nuclear-magnetic-resonance.html

start from September 2018 1 09/05/2018
Colombo Lucia Plant Reproduction

Network controlling fertilization process in Arabidopsis

Inizio da concordare 1 26/02/2018
Colombo Lucia Developmental Biology

Genetic and Epigenetic of organs deveopment in plant

Inizio da concordare 2 26/02/2018
Colombo Lucia Evoluzione dei meccanismi di sviluppo

Evolution of mechanism controlling ovule and seed development

da concordare 1 26/02/2018
La Porta Caterina Biologia Quantitativa

Studio di modelli quantitativi per lo studio di tumori 

guardate il mio sito web:

www.oncolab.unimi.it

1/06/2018 1 26/02/2018
Moroni Anna Andrea Saponaro Engineering of synthetic ion channels

The need to manipulate defined neuronal populations in intact neural circuits in the living experimental animal has long been recognized. The past sev ...

Cosentino C, Alberio L, Gazzarrini S, Aquila M, Romano E, Cermenati S, Zuccolini P, Petersen J, Beltrame M, Van Etten JL, Christie JM, Thiel G,Moroni  ...

da subito 2 07/03/2018
Zuccato Chiara meccanismi allla base delle malattie neurodegenerative

Disfunzioni della sinapsi nella Malattia di Huntington: il ruolo di ADAM10

Gennaio 2019 1 08/03/2018
Fornara Fabio Sviluppo riproduttivo di riso

Il progetto prevede l'analisi della funzione dei geni che cambiano il programma di sviluppo dell'apice meristematico di riso durante l'inizio della fa ...

http://users.unimi.it/fornaralab/

da concordare con il docente 1 26/02/2018
Fornara Fabio Controllo molecolare del periodo di fioritura

In questo progetto lo studente analizzerà il principale gene che in riso è responsabile della misurazione della lunghezza della notte. Il gene è anche ...

http://users.unimi.it/fornaralab/

da concordare con il docente 1 26/02/2018
Chiara Matteo Development of alignment free methods for the detection of structural rearrangement in cancer

Gene fusions are hybrid genes derived from the juxtaposition of previously unrelated genes and functional domains. Gene fusions events can often resul ...

Chiara M, Pesole G, Horner DS. SVM2: an improved paired-end-based tool for the detection of small genomic structural variations using high-throughput  ...

Oct 2018-Jul 2019 1 19/02/2018
Della Torre Camilla Andrea Binelli ecotossicologia

Valutazione della tossicità di nanomateriali su modelli biologici di riferimento mediante analisi di biomarkers e microcospia avanzata

da concordare con il docente 1 27/02/2018
Saponaro Andrea Cosimo Moroni Anna Expression and purification of eukaryotic membrane proteins for structure determination with single particle cryo Electron Microscopy (cryo-EM)

Membrane proteins account for about the 25% of the total amount of eukaryotic proteins, and are often targets for drug design. Indeed, membrane protei ...

to be set (from March 2018) 1 07/03/2018
Saponaro Andrea Cosimo Moroni Anna Study of macromolecular interactions from the biophysical and the structural point of view.

Protein - protein and/or protein - ligand interactions are crucial cellular events, as they are at the basis of signal transduction pathways. Indeed,  ...

  • Saponaro A. et al. Fusicoccin Activates KAT1 Channels by Stabilizing Their Interaction with 14-3-3 Proteins. Plant Cell. 2017 29(10):2570-2580. doi: ...
to be set (from March 2018) 1 07/03/2018
Lenardi Cristina Carsten Schulte (esperto della materia, membro commissione esame Bioimaging Development of hybrid bio-actuators

The mechanotransduction is involved in the regulation of neuronal differentiation and can be guided and fostered by engineering microenvironmental nan ...

01/01/2019-31/12/2019 1 16/03/2018
Aliverti Alessandro Apoptosis Inducing Factor e malattie neurodegenerative

A partire da qualche anno fa, si sta scoprendo un numero rapidamente crescente di varianti alleliche del gene che codifica la proteina mitocondriale A ...

https://www.ncbi.nlm.nih.gov/pubmed/26535916

https://www.ncbi.nlm.nih.gov/pubmed/28666871

settembre 2018 - dicembre 2019 2 13/03/2018
Gnesutta Nerina Bruna Mantovani Structural and functional analysis of transcription factors interactions on DNA

Basi strutturali e funzionali delle interazioni tra fattori trascrizionali sul DNA 

giugno-settembre 2018 0 02/05/2018
Vanoni Maria Antonietta Structure-function studies of flavoenzymes in health and disease

The student will take part to studies on the elucidation of the structure-function relations of flavin-dependent enzymes that have been selected for t ...

Vanoni MA. (2017)  Structure-function studies of MICAL, the unusual multidomain flavoenzyme involved in actin cytoskeleton dynamics. Arch Biochem Biop ...

from June 2018 , to be agreed upon. 2 14/03/2018
Camilloni Carlo Dinamica di proteine e riconoscimento molecolare

I metodo di simulazione computazionale permettono di visualizzare e quantificare il comportamento microscopico di proteine e acidi nucleici. Le tesi d ...

http://sites.unimi.it/camilloni/

From summer 2018 2 14/03/2018
Lenardi Cristina Tommaso Santaniello Development of hybrid bio-actuators

Muscle cells can be used as biological motors. Nowadays, fabrication of such bio-hybrid actuators is mainly focused on two-dimensional systems, thus ...

01/09/2018- 30/06/2018 1 16/03/2018
Martino Bolognesi Eloise Mastrangelo Structure-based design of inhibitors in cancer therapy

The genes for some IAPs (proteins of the inhibitor-of-apoptosis family) are known to be overexpressed in certain tumours. Indeed, IAPblocking  ...

NF023 binding to XIAP-BIR1: searching drugs for regulation of the NF-κB pathway.

Cossu F, Milani M, Grassi S, Malvezzi F, Corti A, Bolognesi M, Mas ...

From October 2018 1 18/03/2018
Beltrame Monica Sox transcription factors in vascular and lymphatic development

We are studying the functional roles of members of the SOX (Sry-related HMG-box) transcription factors in zebrafish, a model organism for vertebrate d ...

Cermenati et al, 2008, Blood, PMID: 18094332; Cermenati et al, 2013, Arterioscler Thromb Vasc Biol., PMID: 23520166; Chiang et al, 2017, Development,  ...

from October 2018 1 19/03/2018
Martino Bolognesi Mario Milani 3D structural characterization of GCAP1 mutants: computational screening and in silico docking search of small molecules interfering with GC-binding

Cone dystrophy (COD) is a severe form of retinal disorder that affects cone photoreceptors and lead to decreased central and color vision and photopho ...

from October 2018 1 20/03/2018
Diletta Dolfini Roberto Mantovani Bioinformatic analysis of gene expression data Settembre 2018 1 23/03/2018
Mantovani Roberto Transcriptional regulation of metabolism in cancer

Trancriptional regulation impacts on cancer cells metabolism. Among the different pathways involved, genes of aminoacids pathways are very often alter ...

Dolfini et al., Stem Cells 30, 2550-2559 (2012).

Nardini et al., Cell 152, 132-143 (2013).

Fleming et al., Genome Res. 23, 1195-1209 (2013).

Benatt ...

September 2018 2 23/03/2018
Horner David Stephen Matteo Chiara Characterization of patterns of phased small RNA production in plants

Phased small RNAs (phasiRNAs) are small (21-34 nt) RNAs produced by a characteristic biogenetic pathway in plants where mRNAs targeted by some microRN ...

https://onlinelibrary.wiley.com/doi/epdf/10.1111/pbi.12882

from September 2018 1-2 25/03/2018
Horner David Stephen Sergio Marchini Genomics of Myxoid liposarcoma

Myxoid liposarcoma is a soft tissue sarcoma and represents one third of all types of liposarcomas. It is a very rare tumour having an incidence of 30  ...

from September 2018 1 25/03/2018
Nardini Marco Giovanna Musco (musco.giovanna@hsr.it) Ospedale San Raffaele Structural Biology

Characterization of the interaction between the PHD-BROMO tandem domain of Sp140 and the protein AIOLOS.

SP140, a lymphoid-restricted homologue of  ...

http://research.hsr.it/en/divisions/genetics-and-cell-biology/biomolecular-nuclear-magnetic-resonance.html

start from September 2018 1 09/05/2018
Nardini Marco Marina Mapelli (marina.mapelli@ieo.it) European Institute of Oncology Structural Biology

Structural studies of asymmetric cell divisions in normal and tumoral intestinal stem cells

The project deals with the structural and biochemical cha ...

https://www.ieo.it/en/RESEARCH/Basic-research/Department-of-Experimental-Oncology/Molecular-basis-of-asymmetric-cell-division-Unit/

start from September 2018 1 09/05/2018
Muzi Falconi Marco Federica Facciotti at IEO Role of the intestinal microbiota in modulating iNKT cell functions during colorectal cancer progression

The project will take advantage of a translational approach involving in vitro systems, murine models of colorectal cancer, 

During the project the p ...

  • Nizzoli G, Burrello C, Cribiù FM, Ercoli G, Botti F, Trombetta E, Rescigno M, Paroni M, Caprioli F* Facciotti F*,“Pathogenicity of in-vivo generated ...
November 2018-November 2019 1 11/05/2018
Muzi Falconi Marco Teresa Manzo at IEO Harnessing the immune system to fight cancer.

Pancreatic Ductal Adenocarcinoma (PDAC) is one of the most refractory tumor to immunotherapy, likely due to its unique immunosuppressive tumor microen ...

  • Gopalakrishnan V*, Nezi L*, Spencer C*, Reuben A, Andrews M, Karpinets T, Prieto P, Vicente D, Hoffman K, Cogdill A, Zhao L, Hudgens C, Hutchinson D ...
September 2018-September 2019 1 11/05/2018
Muzi Falconi Marco Luigi Nezi at IEO Microbiome, Immunology, Cancer

The most recent estimate of microbes populating the human body is around 40 trillion. This means that we are made of bacteria at least as much of huma ...

The  microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients. Gopalakrishnan V*, Spencer CN*, Nezi L*, et al. Science. 2018 Jan  ...

September 2018-September 2019 2 11/05/2018
Muzi Falconi Marco Simona Polo at IFOM Investigating the mechanism of ubiquitin E3 catalysis.

The assembly of ubiquitin chains on substrates is promoted by E3 ligases, yet the mechanisms and regulation of these critical enzymes are poorly under ...

  • Fajner V et al.,Targeting HECT-type E3 ligases - insights from catalysis, regulation and inhibitors. FEBS Lett. 2017 Sep;591(17):2636-2647. 
  • Myant  ...
September/October 2018 for 1 year 1 16/05/2018
Muzi Falconi Marco Stefano Santaguida at IEO UNDERGRADUATE OPPORTUNITY TO STUDY THE CONSEQUENCES OF CHROMOSOME SEGREGATION ERRORS ON CELL PHYSIOLOGY

The newly established Laboratory of Genome Integrity at IEO led by Dr. Stefano Santaguida is looking for an undergraduate student to join the lab in J ...

Santaguida S, RichardsonA, Iyer DR, M’Saad O,Zasadil L, Knouse KA, Wong Y, Rhind N, Desai A, Amon A, Chromosome mis-segregation generates cell cycle-a ...

January 2019 for 1 year 1 11/05/2018
Petroni Katia Dr. Eleonora Cominelli (IBBA-CNR) Plant Molecular Genetics

Phytic acid (InsP6) is the main storage form for phosphate in seeds and in the plant it plays an important role in signal transduction in response to  ...

E. Cominelli, M. Confalonieri, M. Carlessi, G. Cortinovis, M.G. Daminati, T.G. Porch, A. Losa, F. Sparvoli (2018). Phytic acid transport in Phaseolus  ...

already available on May 2018 1 14/05/2018
Briani Federica paolo.landini@unimi.it molecular microbiology

1. Establishment of animal model to investigate pathogenesis of infection by Mycobacterium abscessus members in cystic fibrosis patients

2. Characte ...

Tesi esterne

Per informazioni rivolgersi alla Dr.ssa Daniela Cirillo (HSR)

cirillo.daniela@hsr.it 

da concordare 2 15/05/2018
Popolo Laura Maria Studi molecolari sul recettore umano RAGE

Il progetto mira all'isolamento di nuovi ligandi del recettore e allo studio dell'interazione ligando-recettore. Il progetto si svolge in collaborazio ...

Pubmed e sito web docente

luglio2018-maggio 2019 1 17/05/2018
Michele Simonato (smm@unife.it) Marta Valenza (relatore interno) tesi presso San Raffaele Sviluppo e caratterizzazione di vettori virali per la terapia genica di malattie del sistema nervoso centrale dicembre 2018/gennaio 2019 1 17/05/2018
Petroni Katia Francesca Sparvoli (IBBA-CNR) Genome editing in soybean and common bean

The nutritional and health properties of legume seeds are widely recognised, however the presence of antinutritional factors such as phytic acid (PA), ...

1. E. Cominelli, M. Confalonieri, M. Carlessi, G. Cortinovis, M.G. Daminati, T.G. Porch, A. Losa, F. Sparvoli (2018). Phytic acid transport in Phaseol ...

June 2018 1 30/05/2018
Messina Graziella Yvan Torrente- Policlinico di Milano Distrofia Muscolare
Studio della regolazione epigenetica di geni coinvolti nel differenziamento muscolare
Identificazione di miRNA e proteine contenuti nelle vescicole ...
da concordare con il docente 3 05/06/2018
Nardini Marco Giulio Ferrari (ferrari.giulio@hsr.it), Cornea and Ocular Surface Unit- Eye Repair Lab http://research.hsr.it/en/divisions/neuroscience/eye-repair-la Novel molecular targets in ocular surface inflammation: Substance P and neuropeptides

Our recent observations support a key role of Substance P and other neuropeptides in the generation and maintenance of ocular surface inflammation. Sp ...

to be decided 1 08/06/2018
Nardini Marco Giulio Ferrari (ferrari.giulio@hsr.it) Cornea and Ocular Surface Unit- Eye Repair Lab a The eye-brain loop controlling corneal inflammation: translational implications

We have recently shown that brief, acute inflammation of the ocular surface is able to induce inflammation in the brain, and that this phenomenon is d ...

to be decided 1 08/06/2018
Nardini Marco Dott. Roberto Cuttano, ISBReMIT-San Giovanni Rotondo (FG), cuttano@operapadrepio.it Exploring new therapeutic options for chemoresistant locally advanced lung cancer .
During this project we will investigate the molecular mechanisms that are involved in drug resistance both in vitro and in vivo.
The final aim of the ...
to be defined 1 15/06/2018
Bombarely Aureliano Bioinformatics/Genomics

Optimization of the Assembly of Highly Heterozygous Plant Genomes using Long Reads.

Genome assembly of highly heterozygous genomes is still am import ...

Class about Plant Genome Assembly: https://www.slideshare.net/aubombarely/genome-assembly-2018

Negotiable 1 11/01/2019